![]() Disulfiram: Psychotic reactions can occur do not take concurrently or within the last 2 weeks of disulfiram.Methoxyflurane: Risk of fatal renal toxicity do not co-administer.Discontinue treatment at the first evidence of a cutaneous reaction. Cutaneous Reactions: Stevens-Johnson, toxic epidermal necrolysis, DRESS syndrome.Hepatic Impairment: Not recommended in patients with severe hepatic impairment.Blood Dyscrasias: Use with caution in patients with a history of blood dyscrasias.Photosensitivity: avoid exposure to sun and sun lamps.Monitor patients with CNS conditions closely and discontinue promptly if abnormal neurologic signs develop. Central and Peripheral Nervous System Effects: encephalopathy, convulsive seizures, aseptic meningitis and peripheral neuropathy with metronidazole, intracranial hypertension with tetracycline and neurotoxicity with bismuth-containing products.Tooth Enamel discoloration and hypoplasia: permanent discoloration may develop with use during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years).Maternal Toxicity: Risk of hepatotoxicity in pregnant women with high doses of intravenous tetracycline also resulting in stillborn or premature birth.Fetal Toxicity: Advise pregnant women of the risk throughout pregnancy for retardation of skeletal development seen in animal studies and permanent discoloration of teeth with tetracycline if used during the second or third trimester.
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